Research trials
Find information about ongoing and completed research trials approved by the Ministry of Health.
Overview
Clinical research is fundamental to the practice of medicine and the development of safer, more effective treatment options for patients.
This page contains a list of ongoing and completed research trials approved by the Ministry of Health that include patient care practices that differ from those set out in the Basic Life Support Patient Care Standards and Advanced Life Support Patient Care Standards (as set out in their respective Research Standards).
More information regarding the submission and approval process for proposed research trials can be found in the “Research Trial Submission and Approval Process -v1.0”. For specific questions regarding ongoing or completed research trials, please contact ParamedicStandards@ontario.ca.
Ongoing research trials
| Name of trial | Start date | End date | Principal Investigator (PI) |
|---|---|---|---|
| Double Sequential External Defibrillation for Refractory Ventricular Fibrillation (DOSE-VF) Randomized Controlled Trial | September 3, 2019 | January 31, 2026 | Dr. Sheldon Cheskes Medical Director Sunnybrook Center for Prehospital Medicine Sheldon.Cheskes@sunnybrook.ca |
| Expanding Care by Paramedics to Palliative Patients (EC3P) Study | October 1, 2019 | January 1, 2024 | Dr. Clare Wallner Associate Medical Director Hamilton Health Sciences Centre for Paramedic Education & Research wallnerc@mcmaster.ca |
| Patellar Reduction in the Prehospital Setting (PRPS) Study | December 1, 2019 | January 31, 2026 | Dr. Jason Prpic, CCFP (EM) Health Sciences North Centre for Prehospital Care jprpic@hsnsudbury.ca |
| CanROC Epinephrine Dose: Optimal versus Standard Evaluation Trial (EpiDOSE) Double Blind Randomized Controlled Trial | January 2022 | January 2026 | Dr. Paul Dorian and Dr. Steve Lin, Li Ka Shing Knowledge Institute, St. Michael’s Hospital |
Completed research trials
| Name of trial | Start date | End date | Principal Investigator (PI) |
|---|---|---|---|
| Automated Administration of Oxygen using the FreeO2 Device in Ambulances for COPD and Trauma Patients: A Feasibility Study | December 1, 2019 | June 1, 2021 | Dr. Mike Austin Regional Paramedic Program for Eastern Ontario maustin@toh.ca |
| Prehospital Analgesia in Adults using Inhaled Methoxyflurane: A Feasibility Study | January 2021 | ~3 months after start date | Dr. Mike Austin Regional Paramedic Program for Eastern Ontario maustin@toh.ca |